SN thesis FINAL 191004.pdf (20.87 MB)
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Mechanisms of differentiation therapy response and relapse in acute myeloid leukaemia

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thesis
posted on 09.10.2019, 04:33 authored by Steven Ngo
Differentiation therapy is a highly successful therapy in AML that transforms cancer cells into mature blood cells. Despite its success, some AML patients treated with this therapy still succumb to disease relapse. From my PhD, we found that when cancer cells are transformed into mature blood cells, they turn into multiple different blood cell types. Most cancer cells turn into short living neutrophils, however some cancer cells transform into eosinophil-like cells. These cells are more difficult to clear, persist longer, and are therefore likely to seed relapse. Consequently, preventing AML cells from transforming into eosinophils resulted in a significant reduction in relapse following differentiation therapy.

History

Principal supervisor

Ross Dickins

Additional supervisor 1

Benjamin Kile

Year of Award

2019

Department, School or Centre

Central Clinical School

Additional Institution or Organisation

ACBD

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences