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Mechanisms and Therapeutics of Heart Failure with Preserved Ejection Fraction

posted on 09.10.2019, 04:01 by SHANE SANJEEWA NANAYAKKARA
Heart failure is a condition where the heart’s function does not match the needs of the body. 50% of heart failure cases are due to HFpEF (heart failure with preserved ejection fraction), where there are no effective therapies due in part to a lack of understanding of the mechanisms. In this thesis we explore the underlying causes through detailed pre-clinical and clinical studies, extending to artificial intelligence, and concluding with the first randomised trial of a novel drug.


Principal supervisor

David Martin Kaye

Additional supervisor 1

Melissa Byrne

Year of Award


Department, School or Centre

Central Clinical School

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences