Monash University
Mechanisms and effects of mineralocorticoid receptro signalling in Macrophages.pdf (6.42 MB)

Mechanisms and Effects Of Mineralocorticoid Receptor Signalling in Macrophages

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posted on 2020-08-04, 08:21 authored by SZE YANG GREGORY ONG
The mineralocorticoid receptor (MR) is part of a regulatory system which maintains the balance of salt and fluid in the body. Yet, its presence and role in cells which have no bearing over salt or fluid regulation remains enigmatic. In some disease states, persistent MR activation causes inflammation and scarring potentially disrupting the normal structure and function of blood vessels, the heart, kidneys and other organs. These events are orchestrated in part by signals from immune cells, such as macrophages. This thesis explores the mechanisms of MR action in macrophages, and consequential contributions to inflammation and cardiovascular disease.


Principal supervisor

Morag Young

Additional supervisor 1

Peter Fuller

Year of Award


Department, School or Centre

Medicine - Monash Health

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences