Mechanisms and Effects Of Mineralocorticoid Receptor Signalling in Macrophages

The mineralocorticoid receptor (MR) is part of a regulatory system which maintains the balance of salt and fluid in the body. Yet, its presence and role in cells which have no bearing over salt or fluid regulation remains enigmatic. In some disease states, persistent MR activation causes inflammation and scarring potentially disrupting the normal structure and function of blood vessels, the heart, kidneys and other organs. These events are orchestrated in part by signals from immune cells, such as macrophages. This thesis explores the mechanisms of MR action in macrophages, and consequential contributions to inflammation and cardiovascular disease.