5048464_JLang_Thesis.pdf (28.65 MB)
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Mechanisms Regulating the Increase in Pulmonary Blood Flow at Birth

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posted on 01.06.2017, 04:07 by JUSTIN ANTHONY ROSS LANG
At birth, aeration of the lung stimulates a significant increase in pulmonary blood flow. Despite much research, it remains poorly understood, and a failure to properly transition into newborn life represents a significant source of neonatal morbidity and mortality. The studies in this thesis have used synchrotron X-ray imaging to examine ventilation/perfusion relationships in the lung at birth, suggesting knowledge of this process requires re-evaluation. Partial lung aeration appears to significantly increase pulmonary blood flow, regardless of local aeration or oxygenation. This is a fascinating novel discovery and has implications in delivery room management and the ventilation of newborn infants.


Principal supervisor

Stuart Brian Hooper

Additional supervisor 1

James Pearson

Additional supervisor 2

Graeme Polglase

Year of Award


Department, School or Centre

Obstetrics and Gynaecology

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences

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