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Reason: Under embargo until September 2019. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Mapping therapeutic and biological interactions between immunoregulatory stromal cells and the innate immune system
thesisposted on 2018-09-06, 03:29 authored by JOSHUA D'ROZARIO
Whilst long believed to perform a solely structural role, stromal cells are connective cells within tissues and organs, which have to evolved to play a variety of roles to regulate the immune system. As a result, these cell types have been utilised successfully for immunosuppressive therapies despite many unknowns about their mechanisms of action, kinetics within the body and interactions with the immune system. Here, we investigated two types of stromal cells, the mesenchymal stromal cell (MSC) and fibroblastic reticular cell (FRC) and assessed its therapeutic and biological interactions with the innate immune system.