Monash University
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Manipulating the PAAR proteins of Acinetobacter baumannii

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posted on 2025-03-24, 22:23 authored by Irene Alevizos
The bacteria Acinetobacter baumannii causes a number of life-threatening infections. Aiding in A. baumannii prevalence in hospitals is its ability to attack and kill other bacteria around it, using a spear-like structure called the type six secretion system. This project focused on the sharpening protein at the tip of this spear, called PAAR. We determine the 3D shape of a PAAR protein that had a tail region and showed this protein interacted with other proteins and fats. We also performed PAAR tail “swaps” to determine if we could engineer an antibacterial PAAR protein that targets other bacteria.

History

Principal supervisor

John Dallas Boyce

Additional supervisor 1

Marina Haper

Year of Award

2025

Department, School or Centre

Microbiology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

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