Monash University
Final MS Thesis - Vachara 18108717.pdf (26.78 MB)

Lymphatic Patterns in Primary Cutaneous Squamous Cell Carcinomas of the Head and Neck

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Version 2 2020-08-05, 04:12
Version 1 2020-08-05, 03:33
posted on 2020-08-05, 04:12 authored by VACHARA NIUMSAWATT
In head and neck cutaneous squamous cell carcinoma (cSCC), metastases is thought to be associated with a less well-differentiated cSCCs. However, a recent study found that 15% of well-differentiated cSCCs can metastasise. The ability to visualise lymphatic vessels and better understanding of lymphatic growth has pointed toward the expression of growth factors as an important factor in lymphatic spread. This study reviewed 73 cSCCs specimens using lymphatic endothelial stain (D2-40) which shown an increase in lymphatic numbers, sizes, density and volume in less well differentiated groups. Thus, lymphatic patterns could be used as a prognostic indicator for prognoses and treatments.


Principal supervisor


Additional supervisor 1

A/Prof David Hunter-Smith

Additional supervisor 2

A/Prof Ramin Shayan

Year of Award


Department, School or Centre

Surgery - Monash Health


Master of Surgery

Degree Type



Faculty of Medicine, Nursing and Health Sciences