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Lipid Metabolism in Different Monocyte and Macrophage Subsets in Cardiovascular Disease

thesis
posted on 17.05.2017, 02:21 authored by MAN KIT SAM LEE
Immune cells in our body called macrophages engulf excessive amounts of ‘bad’ cholesterol. This leads to blocked arteries, resulting in the leading cause of death in the world - heart disease. Raising the levels of ‘good’ cholesterol was a therapeutic goal in lowering the risk of heart disease. However, failed clinical trials have brought this idea into question. We discovered that macrophages lose their ability to off-load cholesterol due to a lack of energy, causing over-accumulating ‘bad’ cholesterol. For the first time, we have shown that restoring energy levels, reinstates their ability to off-load cholesterol and could decrease heart disease.

History

Principal supervisor

Andrew Murphy

Year of Award

2017

Department, School or Centre

Medicine - Alfred

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

Doctorate

Faculty

Faculty of Medicine Nursing and Health Sciences