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Reason: Under embargo until May 2018. After this date a copy can be supplied under Section 51 (2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Lipid Metabolism in Different Monocyte and Macrophage Subsets in Cardiovascular Disease
thesisposted on 2017-05-17, 02:21 authored by MAN KIT SAM LEE
Immune cells in our body called macrophages engulf excessive amounts of ‘bad’ cholesterol. This leads to blocked arteries, resulting in the leading cause of death in the world - heart disease. Raising the levels of ‘good’ cholesterol was a therapeutic goal in lowering the risk of heart disease. However, failed clinical trials have brought this idea into question. We discovered that macrophages lose their ability to off-load cholesterol due to a lack of energy, causing over-accumulating ‘bad’ cholesterol. For the first time, we have shown that restoring energy levels, reinstates their ability to off-load cholesterol and could decrease heart disease.