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Large cytoplasmic megakaryocytes are responsible for platelet production and play a critical role in HSC maintenance

thesis
posted on 13.01.2019, 19:36 authored by TANVEER AHMAD
Platelets are the smallest blood cells, which play a key role in blood clotting and wound healing following vascular injury. Thrombocytopenia, a deficiency of circulating platelets, can be life threatening in various clinical conditions. The main focus of this thesis was to investigate platelet generation, to dissect the processes causing thrombocytopenia. A novel population of platelet producing bone marrow cells was identified and characterised, identifying previously unexplored molecular mechanisms regulating platelet generation. The findings presented in this study will provide potential therapeutic opportunities to treat blood related disorders.

History

Principal supervisor

Susan Nilsson

Additional supervisor 1

Minna-Liisa Anko

Year of Award

2019

Department, School or Centre

Australian Regenerative Medicine Institute (ARMI)

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences