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Reason: Under embargo until 9 January 2025. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Kisspeptin (KP-10) Induces Mesenchymal-like Transition and Cell Invasion in Glioblastoma Through RHO Family GTPases

thesis
posted on 2024-01-09, 03:02 authored by MIN YEE CHOW
This thesis examines the detrimental effect of a brain hormone, kisspeptin, in promoting the aggressiveness of a deadly brain tumour, the glioblastoma. This thesis discovers that kisspeptin activates a cell motility program in the tumour cells, which enhances their potential to migrate and invade. This study also found that the use of a drug blocking kisspeptin’s action attenuates the invasiveness of the tumour cells. The findings of this thesis have highlighted the potential of blocking kisspeptin as a promising therapy for glioblastoma patients.

History

Principal supervisor

Muhamad Noor Alfarizal Kamarudin

Additional supervisor 1

Rakesh Naidu

Additional supervisor 2

Syafiq Asnawi Zainal Abidin

Additional supervisor 3

Jeyanthy Eswaran

Year of Award

2024

Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Campus location

Malaysia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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