Monash University
6667640_FinalfullthesisMPM.pdf (8.37 MB)
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Ionophore and Biometal Modulation of P-glycoprotein at the Blood-Brain Barrier

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posted on 2018-06-25, 00:57 authored by MITCHELL PAUL MCINERNEY
This thesis explores the hypothesis that a biometal binding agent is able to deliver enhanced quantities of the biometals zinc and copper into the specialised blood vessel cells which form the interface between the brain and the blood, and subsequently modify the relative abundance and function of P-glycoprotein, an important toxin transporting protein, in both laboratory and animal settings. The successful modulation of P-glycoprotein by biometal delivery may find application in the modification of brain-to-blood transport of natural toxins in Alzheimer's disease, or in the modulation of pharmaceutical access to the central nervous system.


Campus location


Principal supervisor

Joseph Anthony Nicolazzo

Additional supervisor 1

Jennifer L. Short

Year of Award


Department, School or Centre

Drug Delivery, Disposition and Dynamics

Additional Institution or Organisation

Monash Institute of Pharmaceutical Sciences


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences