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Investigations of novel treatment strategies in atherosclerosis and thrombosis

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thesis
posted on 13.11.2018 by ALEX LIN-I HUANG
Heart attack is caused by rupture of atherosclerotic plaques and ensuing clot formation. In this project, new approaches to stop blood clotting was investigated. The first approach targeted neutrophils, an immune cell, through a protein called high mobility group box 1 (HMGB1). It was found this approach is effective and safer than current antithrombotic medications. This thesis also demonstrated that inhibiting the protein, proprotein convertase subtilisin convertase type 9 (PCSK9), in addition to lowering cholesterol, also stabilises atherosclerotic plaque. Combined, these findings may improve the outcome of patients with heart attack and stroke.

History

Principal supervisor

Karlheinz Peter

Additional supervisor 1

Alex Bobik

Year of Award

2018

Department, School or Centre

Medicine - Alfred

Additional Institution or Organisation

Baker Heart and Diabetes Institute

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences

Exports

Exports