Monash University

Embargoed and Restricted Access

Reason: Under embargo until October 2020. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Investigations into the Control of Neural Stem Cell Dynamics by the mTOR-Hmga1a axis.

posted on 2019-10-09, 04:27 authored by DANIEL EDWARD COLQUHOUN
Stem cells make new cells through becoming active and then dividing after which, one cell becomes a functional cell type and the other remains a stem cell. Stem cells then become dormant and so that they can divide again later. hmga1a was found in active stem cells and zebrafish with mutations in this gene show excessive stem cell divisions during development. Hmga1a mutants also have overactive signalling pathways that are important for regulating stem cell activation and division. Hmga1a aids in stem cell maintenance by reducing signalling levels needed for stem cell dormancy needed for life-long survival.


Principal supervisor

Victor Jan Mikael Kaslin

Year of Award


Department, School or Centre

Australian Regenerative Medicine Institute (ARMI)

Additional Institution or Organisation

Australian Regenerative Medicine Institute

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences