Monash University
Final Thesis_Resubmission.pdf (30.02 MB)

Investigation on Neuroprotective Potential of Proteins Extracted from Leaves of Orthosiphon stamineus

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posted on 2020-10-22, 01:30 authored by YIN SIR CHUNG
The key hallmarks in most of the central nervous system disorders are neurotoxicity and neurodegeneration. Neuroprotection has emerged as an alternative treatment strategy. Orthosiphon stamineus (OS; cat’s whiskers; “misai kucing”) is a medicinal plant (Lamiaceae family) with its proteins remain unexplored. This study investigates the neuroprotective potential of proteins extracted from OS leaves (OSLP) on human SH-SY5Y cells and adult zebrafish (Danio rerio). The findings obtained provide new insights into the protein extraction method from OS leaf sample using OTM achievable at laboratory scale, the neuroprotective potential of OSLP against H2O2 stress, and the anticonvulsive potential of OSLP under a normal condition and a hypoxic-ischemic condition.


Principal supervisor

Mohmad Farooq Shaikh

Year of Award


Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)


Doctor of Philosophy

Degree Type