Monash University

Embargoed and Restricted Access

Reason: Under embargo until June 2021. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Investigation of polymyxin-induced immunotoxicity in vitro and in vivo

posted on 2020-08-04, 08:33 authored by AHMED MOHAMED FATHALLA HELAL ELSAYED
Antibiotic resistance is a critical global health threat. Polymyxin antibiotics were revived as the last resort against Gram-negative multidrug-resistant bacteria. The use of aerosolised polymyxins is encouraging, as it allows polymyxin delivery directly to the infection site with limited systemic toxicity and reduced propensity for resistance development. However, there is a significant knowledge gap in the effect of polymyxins on the lung innate immune system, which is critical for optimising their clinical use. Thus, the overall aim of this study was to investigate the potential polymyxin toxicity in human macrophages and neutrophils and to provide mechanistic findings on their immunotoxicity.


Principal supervisor

Jian Li

Year of Award


Department, School or Centre



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences

Usage metrics

    Faculty of Medicine, Nursing and Health Sciences Theses