Investigation of genetic diversity of intestinal parasites and host immune response genes in the Orang Asli community in Malaysia

Over 3.5 billion people worldwide suffer from infections caused by tiny parasitic worms in soil. These infections are common in warm regions, especially in less developed countries. These infections are considered neglected tropical diseases by health organizations. This study focused on the Orang Asli (OA), indigenous population groups residing in Peninsula Malaysia in Southeast Asia, that have a high prevalence of intestinal helminthiasis and aimed to understand their health and genetics. A genetic analysis of immune response genes in the OA communities was conducted to help shed light on variations and disease susceptibility. The discoveries described here offer valuable insights into the genetics of indigenous communities in Southeast Asia and could lead to understanding of intestinal parasitic infections in these populations.