Investigation of Pasteurella multocida pathogenesis using transposon-directed insertion site sequencing and comparative genomics

The bacterium Pasteurella multocida causes several deadly animal diseases. To develop novel therapeutics, we investigated the ability of this bacterium to produce capsule and to survive killing by parts of the chicken immune system. In addition, we looked at the DNA sequences of almost 300 strains of P. multocida to try and discover the genetic basis of how P. multocida causes disease in animals.