Monash University

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Reason: Under embargo until January 2023. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Investigation into the role of sirtuin in modulating Toxoplasma gondii survival: Cellular pharmacology and molecular biology approach

posted on 2022-01-03, 07:04 authored by ZHEN SHERN DING
Toxoplasma gondii is capable of infecting almost any nucleated cell of warm-blooded animals and it is estimated that one-third of the world population is infected with latent toxoplasmosis. To date, there are no effective treatments available to treat and control the spread of this disease, and the survival pathways of this organism remain unclear. This thesis investigates the role of sirtuin in modulating T. gondii survival using sirtuin activators and inhibitors in tandem with gene identification, molecular cloning, protein expression, enzymatic characterization and in silico analysis of this novel parasite protein. Taken together, the findings in the present study suggest that T. gondii Sir2A may not play a role in the survival of RH strain T. gondii.


Campus location


Principal supervisor

Chow Sek Chuen

Year of Award


Department, School or Centre

School of Sciences (Monash University Malaysia)


Doctor of Philosophy

Degree Type



Faculty of Science