Monash University
Davis_21041385_PhD_Thesis_17Feb2023.pdf (5.05 MB)
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Investigating transcranial alternating current stimulation for apathy in Huntington's disease

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posted on 2023-02-17, 05:05 authored by MARIE-CLAIRE DAVIS
Huntington’s disease (HD) is an inherited neurodegenerative disease. Severely reduced motivation, referred to as “apathy”, is a prevalent symptom in HD, with no effective treatments currently available. It presents challenges for people early in their disease course who are otherwise physically and cognitively able to participate in most home, work, and social activities. This thesis demonstrated the safety and acceptability of transcranial alternating current stimulation (tACS) (a type of mild, non-invasive brain stimulation) for people with HD, and generated preliminary evidence of tACS as a means of targeting the underlying brain changes associated with apathy in HD.


Principal supervisor

Kate Hoy

Additional supervisor 1

Aron Hill

Additional supervisor 2

Paul Fitzgerald

Additional supervisor 3

Julie Stout

Year of Award


Department, School or Centre

Central Clinical School

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences