Jiayin_final thesis_revised.pdf (66.61 MB)

Investigating the therapeutic potential of targeting the calcium-sensing receptor in asthma

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thesis
posted on 20.08.2021, 06:16 by JIAYIN DIAO
Asthma affects ~340 million patients worldwide. In severe asthma, symptoms may remain uncontrolled with current treatments. Moreover, current drug therapies do not treat all aspects of asthma. Therefore, new therapeutics are required. The aim of this thesis was to investigate the therapeutic potential of targeting the calcium-sensing receptor (CaSR), a protein target in the airway. My research shows that blocking this protein promotes bronchodilation in mouse airways and provides structural evidence showing how these drugs may work. We expect this data will provide strategies for developing novel drugs for asthma.

History

Campus location

Australia

Principal supervisor

Katie Leach

Additional supervisor 1

Karen J Gregory

Additional supervisor 2

Jane E Bourke

Year of Award

2021

Department, School or Centre

Drug Discovery Biology

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

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