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Investigating the role of the atypical kinase/ATPase RIOK-1 in C. elegans

thesis
posted on 23.04.2021, 01:07 by STEVAN NOVAKOVIC
Ribosomes are complex molecular machines that synthesise the cell's proteins. Assembling ribosomes is complex and requires input from over 200 different proteins. Many of these proteins also have additional roles within the cell, however, these additional roles are not well understood. This thesis used a microscopic worm organism, C. elegans, to examine the function of a ribosome assembly protein called RIOK-1. Important roles for RIOK-1 in regulating development, metabolism and immunity were identified. Mutations in RIOK-1 commonly associated with various cancers, and therefore these results may help us better understand the role of RIOK-1 in human health and disease.

History

Principal supervisor

Peter Boag

Additional supervisor 1

Robin Gasser

Year of Award

2021

Department, School or Centre

Biochemistry and Molecular Biology

Additional Institution or Organisation

Monash Biomedicine Discovery Institute

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE