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Investigating the regulation of mitophagy in the yeast Saccharomyces cerevisiae

thesis
posted on 03.12.2018, 12:19 authored by KAREN LOUISE DAWSON
When stressed, yeast cells react by turning on signalling pathways to selectively degrade mitochondria. This is an important process for cells to survive. If this process does not function correctly, in humans, this could lead to diseases such as Parkinson’s disease and cancer. This thesis investigated the degradation of mitochondria in yeast cells to better understand this process. Two proteins were shown to influence this pathway, likely by affecting the cell wall. The correct positioning of mitochondria near the cell wall was also shown to influence this degradation process.

History

Principal supervisor

Mark Prescott

Year of Award

2018

Department, School or Centre

Biochemistry and Molecular Biology

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences