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Investigating the molecular basis for specific and cross-reactive T cell responses in Celiac Disease

posted on 2023-03-17, 00:41 authored by LAURA CIACCHI

Celiac disease is triggered by ingestion of gluten from wheat, rye and barley in genetically susceptible patients. In the western population, only 1% of individuals develop celiac disease despite 35% being genetically predisposed. This suggests that environmental exposure plays a role in aetiology of disease. This thesis links bacterial exposure with celiac disease as patients could recognise molecular mimics of gluten derived from Pseudomonas species. We uncovered the mechanism behind immune cell recognition of wheat-gluten peptides and bacterially-derived molecular mimics of these peptides. Future efforts to target key interactions identified in this study may offer therapeutic benefit.


Principal supervisor

Jamie Rossjohn

Additional supervisor 1

Hugh H. Reid

Additional supervisor 2

Jan Petersen

Additional supervisor 3

Carine Farenc

Additional supervisor 4

Jason Tye-Din

Year of Award


Department, School or Centre

Biochemistry and Molecular Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences