Adrienne Grech Final Thesis_ExaminerComment Final.pdf (39.69 MB)
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Investigating the interaction between BDNF-TrkB signaling, inhibitory interneurons and cognition with relevance to schizophrenia

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thesis
posted on 04.08.2020, 00:31 authored by ADRIENNE MARY GRECH
Cognitive symptoms of schizophrenia represent a possible therapeutic target. BDNF-TrkB signaling and inhibitory interneurons are considered part of the pathophysiology but the dynamics between them are not fully understood. Three mouse models of altered BDNF-TrkB signaling were used to investigate the interaction with inhibitory interneurons upon behaviour and molecular markers. This thesis supports that BDNF-TrkB signaling and inhibitory interneurons interact with sex to contribute to learning and memory problems. This thesis calls for a stronger research focus on these systems so that preventative and targeted approaches can be developed for schizophrenia.

History

Principal supervisor

Rachel Hill

Year of Award

2019

Department, School or Centre

Psychiatry

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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