Monash University

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Reason: Under embargo until June 2021. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Investigating the effects of activin A and TGFβ superfamily ligands on the fetal male germline

posted on 2020-06-11, 23:06 authored by Sarah Moody
This thesis addresses how disruptions to signalling pathways within the developing testis can alter fetal germ (sex) cell development. I have demonstrated that altered TGFβ superfamily signalling, particularly the growth factor activin A, can directly affect male fetal germ cells. This research is important in the wider context of declining male fertility and increased testicular cancer rates worldwide. Understanding key developmental processes will aid our understanding of how testicular pathologies may arise.


Principal supervisor

Kate Loveland

Additional supervisor 1

Patrick Western

Year of Award


Department, School or Centre

Molecular and Translational Sciences

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences