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Investigating the effects of activin A and TGFβ superfamily ligands on the fetal male germline

thesis
posted on 11.06.2020, 23:06 by Sarah Moody
This thesis addresses how disruptions to signalling pathways within the developing testis can alter fetal germ (sex) cell development. I have demonstrated that altered TGFβ superfamily signalling, particularly the growth factor activin A, can directly affect male fetal germ cells. This research is important in the wider context of declining male fertility and increased testicular cancer rates worldwide. Understanding key developmental processes will aid our understanding of how testicular pathologies may arise.

History

Principal supervisor

Kate Loveland

Additional supervisor 1

Patrick Western

Year of Award

2020

Department, School or Centre

Molecular and Translational Sciences

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

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