Investigating the changes in Inhibitory Neurons following two different models of Traumatic Brain Injury

Different forms of Traumatic brain injury (TBI) disrupt brain excitation/inhibition balance. This thesis examined changes in brain inhibition following two different types of brain injury and its consequences on behaviour. A key finding of this thesis is that particular forms of inhibition are altered after trauma confirming that susceptibility of brain inhibitory cells to trauma is brain area specific, injury type and time dependent. These findings have important implications for evaluation of new treatments for brain injury by targetting particular subsets of brain inhibitory cells as a function of injury type and time.