Monash University

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Investigating the acute and long-term effects of traumatic brain injury on the immune and fibrinolytic system

posted on 2018-04-04, 22:34 authored by MARIA DAGLAS
Traumatic brain injury is a serious condition that results in long-term disability in most patients. This thesis investigated the early and long-term effects of the immune and fibrinolytic response (blood clot breakdown), and the link between these two systems after brain injury in mice. A unique discovery was that the chronic immune response, over a period of 8 months, directly contributes to a worse outcome after brain injury. We also found gender-specific differences occurring at the early stage of injury, that influence recovery, brain-related pathology and the immune response after brain injury, mediated by components of the fibrinolytic system.


Principal supervisor

Robert Lindsay Medcalf

Year of Award


Department, School or Centre

Australian Centre for Blood Diseases

Additional Institution or Organisation

Clinical Haematology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences