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Investigating the Therapeutic Utility of Human Amniotic Epithelial Cell-derived Exosomes in Pulmonary Arterial Hypertension

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thesis
posted on 2024-05-10, 05:23 authored by PENG-CHENG WANG
Pulmonary hypertension (high blood pressure in the lungs), is an incurable and often fatal disease. It is more prevalent in females yet more severe in males. Existing drugs provide only partial relief and do not target the underlying cause of the disease. This thesis provided new insight into the use of a pre-clinical model of pulmonary hypertension to simulate the human condition in both males and females. Using this model, tiny cell-derived structures (exosomes) from human placenta, were shown to reduce lung blood pressure and inflammation. This exciting discovery offers new hope for the treatment of patients with pulmonary hypertension.

History

Principal supervisor

Barbara Kemp

Year of Award

2024

Department, School or Centre

Pharmacology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

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