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Investigating the Role of Neutrophil Glucose Metabolism in Inflammation and Diabetes-Associated Myelopoiesis and Atherosclerosis

thesis
posted on 12.04.2021, 06:02 by MICHELLE CHRISTINE FLYNN
Neutrophils contribute to the pathogenesis of a number of inflammatory diseases, often linked to either global metabolic disturbances and/or changes to immune cell metabolism. Herein, we explored the role of neutrophil glucose metabolism in promoting inflammation in diabetes. We modelled this in the context transient and intermittent hyperglycaemia prevalent in patients with seemingly well controlled glucose levels, to explore the contribution to atherosclerosis. We also reveal novel functions for potential regulators of neutrophil glucose metabolism: GLUT-6 (uptake) and hexokinase-3 (1-step metabolism) in mediating diabetes and inflammation associated neutrophil production and function.

History

Principal supervisor

Andrew Murphy

Additional supervisor 1

Man Kit Sam Lee

Year of Award

2021

Department, School or Centre

Immunology - Alfred

Additional Institution or Organisation

Baker Heart and Diabetes Institute

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE