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Investigating post-translational regulation of GILZ: Towards a new anti-inflammatory therapy

thesis
posted on 15.09.2021, 07:29 by Mehnaz Pervin
Glucocorticoid-induced leucine zipper (GILZ) is a TSC22 domain family protein induced by GC. This study was designed to examine the post-translational modifications of GILZ and to catalogue its interacting partners, with the aim of gaining a better understanding of how to design a new anti-inflammatory therapy to increase the abundance of GILZ. We investigated the post-translational modifications (PTMs), specifically ubiquitination and phosphorylation of GILZ. The research outcomes from this project may provide new opportunities to target the specific anti-inflammatory actions of GILZ without the devastating side effects of long-term steroid use.

History

Principal supervisor

Sarah Jones

Additional supervisor 1

Dr James Harris

Additional supervisor 2

Dr Jacqueline Flynn

Year of Award

2021

Department, School or Centre

Medicine - Monash Health

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences