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Reason: Under embargo until 31 May 2025. After this date a copy can be supplied under Section 51 (2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Investigating nanoparticle based vaccines for the optimal induction of CD8 + T cell responses against minimal peptide epitopes

thesis
posted on 2017-05-09, 07:05 authored by KIRSTY LEE WILSON
Peptide based vaccines are safe and cost effective, however, they require an adjuvant to enhance the immune response. Current licensed adjuvants are poor inducers of CD8 T cells, thus there is a need for novel adjuvant systems. This study established that it is possible to induce potent CD8 T cell responses to minimal peptide targets, when using delivery systems such as peptides bound to nanoparticles, or nanoparticles in combination with immune potentiators. This study advances the understanding of principles for developing a new generation non-inflammatory vaccines against minimal peptide CD8 T cell targets.

History

Principal supervisor

Magdalena Plebanski

Additional supervisor 1

Sue Xiang

Year of Award

2017

Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Department of Immunology and the Department of Pathology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

Doctorate

Faculty

Faculty of Medicine Nursing and Health Sciences

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    Faculty of Medicine, Nursing and Health Sciences Theses

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