Monash University

Embargoed and Restricted Access

Reason: Under embargo until 31 May 2024. After this date a copy can be supplied under Section 51 (2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Investigating nanoparticle based vaccines for the optimal induction of CD8 + T cell responses against minimal peptide epitopes

posted on 2017-05-09, 07:05 authored by KIRSTY LEE WILSON
Peptide based vaccines are safe and cost effective, however, they require an adjuvant to enhance the immune response. Current licensed adjuvants are poor inducers of CD8 T cells, thus there is a need for novel adjuvant systems. This study established that it is possible to induce potent CD8 T cell responses to minimal peptide targets, when using delivery systems such as peptides bound to nanoparticles, or nanoparticles in combination with immune potentiators. This study advances the understanding of principles for developing a new generation non-inflammatory vaccines against minimal peptide CD8 T cell targets.


Principal supervisor

Magdalena Plebanski

Additional supervisor 1

Sue Xiang

Year of Award


Department, School or Centre

Department of Immunology and Pathology. Central Clinical School

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences