Investigating hnRNPA1-IAV NP interactions and their role in IAV life cycle

The aim of this Ph.D. thesis was to investigate and characterise the role of Human Heterogeneous ribonucleoprotein A1 (hnRNPA1) in Influenza A virus life cycle. We found that hnRNPA1 exerts a protective role in Influenza A infection as enhancing hnRNPA1 levels, impaired viral replication and vice versa. Furthermore, it was deciphered that Nucleoprotein of IAV interacts with hnRNPA1 to subvert and co-opt pro-survival and cell death signaling pathways in infection. Thereby, substantiating it's anti-viral function.