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Reason: Under embargo until June 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Investigating hnRNPA1-IAV NP interactions and their role in IAV life cycle
thesis
posted on 2021-06-20, 07:12 authored by RAMANDEEP KAURThe aim of this Ph.D. thesis was to investigate and characterise the role of Human Heterogeneous ribonucleoprotein A1 (hnRNPA1) in Influenza A virus life cycle. We found that hnRNPA1 exerts a protective role in Influenza A infection as enhancing hnRNPA1 levels, impaired viral replication and vice versa. Furthermore, it was deciphered that Nucleoprotein of IAV interacts with hnRNPA1 to subvert and co-opt pro-survival and cell death signaling pathways in infection. Thereby, substantiating it's anti-viral function.
