Monash University

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Reason: Under embargo until July 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Investigating factors regulating the expression and function of P-glycoprotein and breast cancer resistance protein at the blood-brain barrier

posted on 2021-07-15, 10:42 authored by STEPHANIE ALEXANDRA NEWMAN
P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are two protein ‘pumps’ situated at the cellular interface separating the brain from the general blood circulation. Whilst these proteins mainly serve to prevent accumulation of potential toxins and waste products in the brain, they greatly reduce the brain delivery of therapeutic drugs to treat brain diseases and are thought to mediate the transport of a toxic substance involved in Alzheimer’s disease. Therefore, this thesis investigated factors regulating the abundance and activity of P-gp and BCRP, which may have application for improving brain drug delivery or the treatment of Alzheimer’s disease.


Campus location


Principal supervisor

Joseph Anthony Nicolazzo

Additional supervisor 1

Jennifer Short

Year of Award


Department, School or Centre

Drug Delivery, Disposition and Dynamics

Additional Institution or Organisation

Monash Institute of Pharmaceutical Sciences


Doctor of Philosophy

Degree Type



Faculty of Pharmacy and Pharmaceutical Sciences