MingShen Tham Thesis No signature.pdf (13.93 MB)

Investigating a role for Aurora Kinase A in cystic kidney disease

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thesis
posted on 23.03.2021, 04:53 by MING SHEN THAM
Polycystic kidney disease (PKD) is a condition which causes the kidneys to lose its function due to the development of multiple cysts. It is caused by mutations in several genes such as INPP5E or PKD1/2. This thesis shows that genetic knockout of Inpp5e or Pkd1 in conjunction with Aurora Kinase A (Aurka) can ameliorate PKD in mice, thereby identifying AURKA as a contributor to this condition. The mechanism by which AURKA causes PKD is also explored. Overall, this thesis suggests that the development of drugs which disrupt AURKA may prove promising for PKD treatment.

History

Principal supervisor

Ian Macleod Smyth

Additional supervisor 1

Sharon Ricardo

Additional supervisor 2

Denny Luke Cottle

Year of Award

2021

Department, School or Centre

Anatomy and Developmental Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE