Monash University
MingShen Tham Thesis No signature.pdf (13.93 MB)

Investigating a role for Aurora Kinase A in cystic kidney disease

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posted on 2021-03-23, 04:53 authored by MING SHEN THAM
Polycystic kidney disease (PKD) is a condition which causes the kidneys to lose its function due to the development of multiple cysts. It is caused by mutations in several genes such as INPP5E or PKD1/2. This thesis shows that genetic knockout of Inpp5e or Pkd1 in conjunction with Aurora Kinase A (Aurka) can ameliorate PKD in mice, thereby identifying AURKA as a contributor to this condition. The mechanism by which AURKA causes PKD is also explored. Overall, this thesis suggests that the development of drugs which disrupt AURKA may prove promising for PKD treatment.


Principal supervisor

Ian Macleod Smyth

Additional supervisor 1

Sharon Ricardo

Additional supervisor 2

Denny Luke Cottle

Year of Award


Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Anatomy and Developmental Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences