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Investigating Structural Aspects and Opportunities in Solid Dispersing Lipid- Based Drug Formulations

thesis
posted on 05.02.2019, 22:17 by KAPILKUMAR ARVINDBHAI VITHANI
Lipid-based formulations have been researched for many years as a viable means to improve the oral bioavailability of poorly water-soluble lipophilic compounds. Among other developed lipid-based formulations, self-microemulsifying drug delivery system (SMEDDS) received an increased interest due to improved formulation and dispersion behaviours. Thus, the first part of the thesis investigates the evolution of colloidal phases during dispersion and digestion, and examine the solubilisation behaviour of lipophilic drugs during digestion. And, the second part of the research focuses on implementation of 3D printing technology for the preparation of solid-phase carrier-free solid SMEDDS formulations.

History

Campus location

Australia

Principal supervisor

Ben Boyd

Additional supervisor 1

Colin Pouton

Additional supervisor 2

Vincent Jannin

Year of Award

2019

Department, School or Centre

Drug Delivery, Disposition and Dynamics

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences