Monash University

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Reason: Under embargo until 3 May 2025. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Investigating SOX9 downstream genes Tyro3 and Trpc3 in mammalian testis development

posted on 2024-05-02, 23:25 authored by ZHENHUA MING
This research explores SOX9, a crucial gene for male sex development. Mutations in SOX9 contribute to sex development differences. In mice, SOX9 determines if an embryo becomes male or female. The study investigates two new genes, TYRO3 and TRPC3, linked to SOX9. Inhibiting TYRO3 in male mice reduces germ cells, affecting testis development. Similarly, TRPC3 disruption leads to fewer germ cells and a disturbed coelomic blood vessel. The findings enhance our understanding of SOX9, providing insights into male sex development and potential causes of sex development differences. This knowledge could advance diagnoses for sex development disorders and improve understanding of fertility issues.


Principal supervisor

Vincent Harley

Additional supervisor 1

Stefan Bagheri-fam

Additional supervisor 2

Emily Frost

Year of Award


Department, School or Centre

Molecular and Translational Sciences

Additional Institution or Organisation

Hudson Institute of Medical Research

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences