Monash University

Embargoed and Restricted Access

Reason: Under embargo until March 2025. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library, or by emailing

Investigating Cyst Initiation and Growth in Polycystic Kidney Disease

posted on 2022-03-02, 05:39 authored by Allara Karin Zylberberg
Polycystic Kidney Disease (PKD) is an inherited disorder where fluid filled sacs, called cysts, develop primarily in the kidney. Over time, this causes the kidney to enlarge and lose function. PKD varies in severity and is caused by abnormal genes. This thesis discovered that removing a gene known as Aurka Kinase A in conjunction with the abnormal PKD genes can improve this disease in mice, therefore identifying it as a contributor to this condition. This thesis further demonstrated that modulating the immune response can also lessen disease severity. Overall, this thesis identifies two potential future therapeutic interventions for PKD.


Principal supervisor

Ian Macleod Smyth

Additional supervisor 1

John Bertram

Year of Award


Department, School or Centre

Anatomy and Developmental Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences