Embargoed and Restricted Access
Reason: Under embargo until July 2019. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
Intracellular delivery of p53 gene, siRNAs against oncogenes and anti-cancer drugs using pH-sensitive inorganic nanoparticles for induction of cell death in breast cancer cells
Version 2 2020-07-10, 03:23
Version 1 2018-07-16, 04:16
thesis
posted on 2020-07-10, 03:23 authored by TAHEREH FATEMIANWith the aim to enrich the therapeutic profile of classical anti-cancer drugs, inorganic pH dependent carbonate apatite (CA) nanoparticles were utilized to efficiently deliver various drugs and also genetic materials into cancer cells. Following characterization and various modifications in the structure of CA complexes with different therapeutics, lifted outcomes were achieved. Markedly, enhanced anti-cancer efficacy was attained via application of CA formulations of therapeutics in cell culture and animal model. Additionally, synergistic interactions against cancer cells were documented following administration of CA preparations carrying drugs and genetic materials compared to free drugs.
