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Intracellular Drug Delivery: A Route to More Selective and Effective Treatments for Disease

thesis
posted on 30.01.2019, 03:52 by QUYNH NHU MAI
The Neurokinin 1 receptor (NK1R) is widely expressed in humans and contributes to the regulation of inflammation, gastrointestinal function and pain transmission. Recent research has revealed new relationships between NK1R location and function, and has shown that intracellular NK1R populations are important for driving diseases such as chronic inflammation and pain. We proposed that the efficient and selective delivery of drugs to compartmentalised receptor populations in compartments known as endosomes, will therefore have important implications for drug discovery. This thesis explores novel drug delivery strategies and has demonstrated that drug-lipid modifications and nanoparticles can selectively target the signalling of the NK1R inside cells to improve disease outcomes.

History

Principal supervisor

Nicholas Veldhuis

Additional supervisor 1

Christopher Porter

Additional supervisor 2

Nigel Bunnett

Additional supervisor 3

Stephen Hill

Year of Award

2019

Department, School or Centre

Drug Discovery Biology

Additional Institution or Organisation

The University of Nottingham

Course

Doctor of Philosophy (Joint Award and Doctoral Training Centre with The University of Nottingham)

Degree Type

DOCTORATE

Faculty

Faculty of Pharmacy and Pharmaceutical Sciences

Exports

Exports