Monash University

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Reason: Under embargo until February 2020. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Interaction between Poly (C)-Binding Protein 2 and Poliovirus Stem-loop IV RNA as the primary step in poliovirus IRES-dependent translation

posted on 2019-02-13, 22:27 authored by MEHDI YOUSSEFI MATAK
Poliovirus hijacks the host cell’s machinery to produce its own proteins for further propagation in the infected cell. In doing this, the virus uses the human protein PCBP2. My project was to investigate, on a molecular level, how the 3D structures in the viral genome attracts PCBP2 and utilizes this protein-RNA hybrid system to recruit the ribosome that reads the viral genome. This work might lead to the development of new therapeutic ways to stop viruses.


Principal supervisor

Matthew Charles James Wilce

Additional supervisor 1

Jacqueline Anne Wilce

Additional supervisor 2

Simone Alexandra Beckham

Year of Award


Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Biochemistry and Molecular Biology

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences