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Interaction between Poly (C)-Binding Protein 2 and Poliovirus Stem-loop IV RNA as the primary step in poliovirus IRES-dependent translation

thesis
posted on 13.02.2019, 22:27 by MEHDI YOUSSEFI MATAK
Poliovirus hijacks the host cell’s machinery to produce its own proteins for further propagation in the infected cell. In doing this, the virus uses the human protein PCBP2. My project was to investigate, on a molecular level, how the 3D structures in the viral genome attracts PCBP2 and utilizes this protein-RNA hybrid system to recruit the ribosome that reads the viral genome. This work might lead to the development of new therapeutic ways to stop viruses.

History

Principal supervisor

Matthew Charles James Wilce

Additional supervisor 1

Jacqueline Anne Wilce

Additional supervisor 2

Simone Alexandra Beckham

Year of Award

2019

Department, School or Centre

Biochemistry and Molecular Biology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine Nursing and Health Sciences