Monash University

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Reason: Under embargo until November 2022. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library

Insights into the regulatory architecture of the Trunk-to-Tail transition and mechanisms constraining vertebral number in mouse

posted on 2021-11-25, 05:21 authored by GABRIEL MARKUS HAUSWIRTH
The vertebral column of individual mammalian species often exhibits remarkable robustness in the number and identity of vertebral elements that form (known as axial formulae). Between mammalian species however, great diversity in axial formulae has arisen due to natural selection. This thesis investigates the underlying gene-regulatory mechanisms that unfold during mouse embryonic development to produce a robust axial formula. Specifically, the genetic manipulation of Gdf11, Retinoic acid and microRNA-196 activity, individually and cumulatively, led to the formation of additional vertebral elements. Moreover, this work revealed a highly unexpected role for posterior Hox genes in supporting the growth of tail structures.


Principal supervisor

Edwina Mcglinn

Additional supervisor 1

Fernando J. Rossello

Year of Award


Department, School or Centre

Australian Regenerative Medicine Institute (ARMI)

Additional Institution or Organisation

EMBL Australia, Monash University, Clayton, Vic, 3800, Australia.

Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine, Nursing and Health Sciences