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Insights into the regulatory architecture of the Trunk-to-Tail transition and mechanisms constraining vertebral number in mouse
thesisposted on 2021-11-25, 05:21 authored by GABRIEL MARKUS HAUSWIRTH
The vertebral column of individual mammalian species often exhibits remarkable robustness in the number and identity of vertebral elements that form (known as axial formulae). Between mammalian species however, great diversity in axial formulae has arisen due to natural selection. This thesis investigates the underlying gene-regulatory mechanisms that unfold during mouse embryonic development to produce a robust axial formula. Specifically, the genetic manipulation of Gdf11, Retinoic acid and microRNA-196 activity, individually and cumulatively, led to the formation of additional vertebral elements. Moreover, this work revealed a highly unexpected role for posterior Hox genes in supporting the growth of tail structures.
Principal supervisorEdwina Mcglinn
Additional supervisor 1Fernando J. Rossello
Year of Award2021
Department, School or CentreAustralian Regenerative Medicine Institute (ARMI)
Additional Institution or OrganisationEMBL Australia, Monash University, Clayton, Vic, 3800, Australia.
CourseDoctor of Philosophy
FacultyFaculty of Medicine, Nursing and Health Sciences