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Innate immune mechanisms of the pathogenesis of MPO-ANCA Vasculitis

thesis
posted on 2023-09-07, 02:40 authored by SHARON LEE FORD
MPO-ANCA Vasculitis is a severe inflammatory disease which can cause kidney failure and death. Current treatments are non-specific and toxic. This thesis examined methods of predicting disease outcome in a group of Australian patients. Mechanisms of disease were further explored using experimental models to define critical regulators of inflammation. Collectively these understandings facilitate the design of more targeted therapies for patients with MPO-ANCA Vasculitis.

History

Principal supervisor

Poh Yi Gan

Additional supervisor 1

Kim O'Sullivan

Additional supervisor 2

Richard Kitching

Year of Award

2023

Department, School or Centre

Medicine - Monash Health

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences