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Inhibitory potential of geraniin and its metabolites extracted from the rind of rambutan (Nephelium lappaceum) against dengue virus type-2

thesis
posted on 25.05.2017, 00:16 by SITI AISYAH ABDUL AHMAD
Just as rambutan is a common seasonal fruit, dengue is a common seasonal disease to the Southeast Asians. The four types of dengue viruses (DENV-1 to 4) are causing havoc across the globe as there is no specific treatment exists to treat the infections. Our study was thus, aimed at investigating the potential of a compound called geraniin, which is extracted from the rind of rambutan, in inhibiting DENV-2. Through a series of experiments, we had proven that geraniin can inhibit DENV-2 in-vitro, as well as in-vivo. Hence, geraniin has the potential to be developed as a future anti-dengue drug.

History

Principal supervisor

Sharifah Syed Hassan

Additional supervisor 1

Uma Devi Palanisamy

Year of Award

2017

Department, School or Centre

Jeffrey Cheah School of Medicine and Health Sciences (Monash University Malaysia)

Campus location

Malaysia

Course

Doctor of Philosophy

Degree Type

Doctorate

Faculty

Faculty of Medicine Nursing and Health Sciences

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