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Telianidis THESIS - Amended.pdf (9.82 MB)

Inhibition of Insulin-Regulated Aminopeptidase: A Novel Therapeutic Strategy for Stroke

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thesis
posted on 2022-11-07, 23:50 authored by JONATHON TELIANIDIS
This thesis characterises and validates a preclinical model of stroke that closely mimics human stroke. In this preclinical model, novel drug therapies that target the insulin-regulated aminopeptidase (IRAP), an enzyme found in the brain, were tested. This thesis identified that following stroke, targeting IRAP reduces tissue damage in the brain and improves physical mobility.

History

Principal supervisor

Siew Yeen Chai

Additional supervisor 1

Claudia McCarthy

Additional supervisor 2

Vi Pham

Year of Award

2022

Department, School or Centre

Biomedical Sciences (Monash Biomedicine Discovery Institute)

Additional Institution or Organisation

Physiology

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences