Inhibition of Insulin-Regulated Aminopeptidase: A Novel Therapeutic Strategy for Stroke

This thesis characterises and validates a preclinical model of stroke that closely mimics human stroke. In this preclinical model, novel drug therapies that target the insulin-regulated aminopeptidase (IRAP), an enzyme found in the brain, were tested. This thesis identified that following stroke, targeting IRAP reduces tissue damage in the brain and improves physical mobility.