Monash University

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Inflammation, hypercholesterolemia, vascular dysfunction and sex differences in hypertension

posted on 2017-07-05, 23:38 authored by QUYNH NHU DINH
While high blood pressure, also known as hypertension, is a major health burden, in ~90% of cases the underlying cause is unknown. These doctoral studies sought to better understand mechanisms contributing to hypertension. Inflammation has been linked to hypertension, but I found that the presence of inflammation alone was insufficient to cause hypertension. However, I found that one contributing factor could be an increased sensitivity to the pro-hypertensive effects of angiotensin II that develops in advanced age. I also found that activating certain estrogen receptors may be a viable therapy to treat some hypertension cases in both sexes.


Principal supervisor

Christopher Sobey

Year of Award


Department, School or Centre


Campus location



Doctor of Philosophy

Degree Type



Faculty of Medicine Nursing and Health Sciences