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Amy Wilson_PhD Thesis_final.pdf (38.98 MB)

Improving in vivo detection methods and immunotherapies for epithelial ovarian cancer

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thesis
posted on 2020-04-02, 04:19 authored by AMY LOUISE WILSON
Epithelial ovarian cancers (EOCs) are the most lethal of all female reproductive-associated cancers. The immune system plays a significant role in the progression of EOC, thus therapies that can re-activate the anti-tumour immune response are promising; however, improved animal models are required in order to accurately assess new therapies effectively. We developed a new ovarian cancer mouse model that permits tracking of ovarian cancer progression non-invasively in real time. We used this model to show that a type 2 diabetes drug can restore the immune response and delay ovarian cancer progression, both alone and in combination with chemotherapy. This exciting work will hopefully lead to a new treatment for ovarian cancer.

History

Principal supervisor

Magdalena

Additional supervisor 1

Dr. Andrew Stephens

Additional supervisor 2

A/Prof. Mark Wright

Additional supervisor 3

Dr. Kirsty Wilson

Year of Award

2020

Department, School or Centre

Central Clinical School

Additional Institution or Organisation

Immunology - Alfred

Campus location

Australia

Course

Doctor of Philosophy

Degree Type

DOCTORATE

Faculty

Faculty of Medicine, Nursing and Health Sciences