Monash University
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Improved control of granule properties via "steady state granulation"

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posted on 2017-02-23, 01:54 authored by Moo, Ryan Fei Tzhung
The thesis presented the understanding and application of “steady state” granulation approach in high shear wet granulation to produce granules that have better control of properties to be used as an oral solid dosage form as opposed to being compressed into tablets in industrial practices. The approach aims to achieve a "steady state" condition that is unachievable in conventional wet granulation processes. Two key operating parameters, liquid delivery rate and wet massing time are adjusted in order to evenly distribute the granulating fluid across the powder system. The approach showed to be feasible in producing granules that were narrow in size distribution, considerably spherical, smooth-surfaced and also possessed good and controlled dissolution performance. Current findings open up potential avenues in the design of drug carrier suitable for children.


Campus location


Principal supervisor

Karen Hapgood

Year of Award


Department, School or Centre

Chemical & Biological Engineering

Additional Institution or Organisation

Chemical Engineering


Master of Engineering Science (Research)

Degree Type



Faculty of Engineering

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    Faculty of Engineering Theses


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